The forth season of Face Off features 14 prosthetic makeup artists competing against each other to create makeup effects. The grand prize for the fourth season is a position as a guest lecturer at the Make Up for Ever Academies in New York and Paris, a 2013 Fiat 500, and US$100,000.
Foundation Challenge: On the Queen Mary, the contestants must use a crown as inspiration for an original queen make-up that represents them as an artist.
Guest Judge: Michael Westmore
Reward: Immunity
Winner: Anthony
Spotlight Challenge: Working in teams of two, the artists must create believable fantasy goblin kings based on one of seven terrains.
Guest Judge: John Rhys-Davies
Top Looks: Anthony & Meagan, Eric F. & Jenna and Eric Z. & Autumn
Bottom Looks: Michael & Troy and Wayne & Alexandra
Spotlight Challenge: While visiting the 2012 San Diego Comic Con, the remaining artisits must create an original DC Comics superhero as well as working on their concept with several DC artists.
Reward: The winning superhero will be featured in the Justice League Dark issue #16.
Guest(s): Dan DiDio, Jim Lee, Nicola Scott, Mark Buckingham, Cliff Chiang, Tony S. Daniel, David Finch and J.H. Williams III
Spotlight Challenge: Working in teams of two, the artists must each create their own take on one of the mentioned demons above. While at the desert, the heat put them in right frame of mind creating their hellish demons. But back at the lab they were given the script-note that "Hell has frozen over", thus the teams then must work this detail into their designs.
Top Looks: Anthony & Alam and Wayne & Eric F.
Bottom Looks: Alexandra & Autumn and Jenna & Katie
Spotlight Challenge: The artists work in teams of two to create a larger-than-life giant character based on Jack the Giant Killer. Their character should have 2 or more heads.
Guest Judge: Bryan Singer
Top Looks: Wayne & House, Anthony & Autumn, Eric F. & Kris
Spotlight Challenge: The artists visit the set of the new Syfy television series Defiance where they are tasked to create an original make-up that puts forth a possible hybrid offspring of two of the show's alien races.